Amazing new insights about working in the world of science and
technology poured out of a meeting last week while I was working
on other things.
They are so thoughtful and inspiring it is worth sharing them
and making the case that smaller (boutique) societies have
incredible value. What they aim to do is look for the unmet
needs of the larger, very topic oriented (silos of sub-disciplines).
They seek out the intersections of fields and the forefronts of
research often outside of the realm of the larger industrial
On reflection, three outstanding findings are shared in this
contribution about SlAS2016: insights into resistance to
drug therapies of diseases (cancers and ’superbugs’), crowdfunding
research, and tackling high risk, never performed team projects
with unknown outcomes.
Shana Kelley of UToronto reported chip based microfluidic
devices using electrochemical assays to identify the bacteria
to know the proper therapies to apply. Each year it is
estimated that 2 million US cases of antibiotic resistant
infections, which can be caused by over use of prescription
drugs or employing the wrong agent for the infection.
An assay of redox active molecules that measures the levels
of metabolically active bacteria it the telling step in the device.
Anecdotally, having a tool like this available 90 years ago might
have saved Calvin Coolidge’s younger son.
Michael Gottesmann of NCI spoke about drug resistance found
during cancer treatment that involve at least four different
mechanisms: target mutation, genetic mutation, cell type
changes and alterations of physiology (of blood or organs).
Cell models do not model in vivo gene expression. calls for
coordinated treatment regimens of multiple mechanisms.
K Tom Pickard presented the case for a different research
sponsorship model that uses — “be viable or vanish”. He cited
how this is becoming a viable approach to deal with shortfalls
in resources and seek out other sources that can have a
purposeful, entrepreneurial or doing the right thing motivation.
His primary focus is autism and he reported on use of
twitter, social media and kickstarter/ experiment.com .
Teamwork to achieve high risk goals
Adam Steitzner amazed the audience with the story of landing the
Mars Rover on the surface of Gale Crater to answer the question
of whether there was/is life on Mars… 100 million miles away.
- Separate people from ideas
- Lunch with Enrico
Get to know and like all the people you work with
- Plan to change plans
- Many times the answers we seek are in the questions
Challenge all assumptions